Source: Office of Research Services, University of Pennsylvania
Source: National Science Foundation, National Center for Science and Engineering Statistics, Higher Education R&D Survey (Dollars in thousands)
| Rank | Institution | R&D Expenditures |
| 1 | Johns Hopkins University | $2,917,436 |
| 2 | University of Michigan, Ann Arbor | $1,675,805 |
| 3 | University of California, San Francisco | $1,595,098 |
| 4 | University of Pennsylvania | $1,506,285 |
| 5 | University of Washington, Seattle | $1,425,601 |
| 6 | University of California, San Diego | $1,353,763 |
| 7 | University of California, Los Angeles | $1,306,376 |
| 8 | University of Wisconsin-Madison | $1,297,331 |
| 9 | Harvard University | $1,239,736 |
| 10 | Duke University | $1,226,517 |
| 11 | Stanford University | $1,204,116 |
| 12 | University of North Carolina at Chapel Hill, The | $1,153,773 |
| 13 | Cornell University | $1,144,534 |
| 14 | University of Maryland | $1,096,600 |
| 15 | University of Pittsburgh, Pittsburgh | $1,080,951 |
| 16 | Yale University | $1,072,309 |
| 17 | University of Minnesota, Twin Cities | $1,013,112 |
| 18 | Massachusetts Institute of Technology | $1,009,466 |
| 19 | Columbia University in the City of New York | $1,003,615 |
| 20 | University of Texas (Cancer Center) | $917,744 |
Source: Penn Center for Innovation
Source: Office of Research Services, University of Pennsylvania
Source: Pennovation
| Rank | Institution |
| 1 | University of Utah |
| 2 | Columbia University |
| 3 | University of Florida |
| 4 | Brigham Young University |
| 5 | Stanford University |
| 6 | University of Pennsylvania |
| 7 | University of Washington |
| 8 | Massachusetts Institute of Technology |
| 9 | California Institute of Technology |
| 10 | Carnegie Mellon University |
| Rank | Institution | Country |
| 1 | Stanford University | USA |
| 2 | Massachusetts Institute of Technology | USA |
| 3 | Harvard University | USA |
| 4 | University of Pennsylvania | USA |
| 5 | University of Washington | USA |
| 6 | University of North Carolina, Chapel Hill | USA |
| 7 | KU Leuven | Belgium |
| 8 | University of Southern California | USA |
| 9 | Cornell University | USA |
| 10 | Imperial College London | UK |
Members of distinction of the faculty, active and emeritus: Source upenn.edu/about/facts
In the past two decades: Source upenn.edu/about/facts