Source: National Science Foundation, National Center for Science and Engineering Statistics, Higher Education R&D Survey (Dollars in thousands)
| Rank | Institution | R&D Expenditures |
| 1 | Johns Hopkins University | $2,562,307 |
| 2 | University of Michigan, Ann Arbor | $1,530,139 |
| 3 | University of California, San Francisco | $1,409,398 |
| 4 | University of Pennsylvania | $1,374,293 |
| 5 | University of Washington, Seattle | $1,348,220 |
| 6 | University of Wisconsin-Madison | $1,193,413 |
| 7 | University of California, San Diego | $1,133,454 |
| 8 | Duke University | $1,126,924 |
| 9 | Harvard University | $1,123,160 |
| 10 | Stanford University | $1,109,708 |
| 11 | University of North Carolina at Chapel Hill, The | $1,102,063 |
| 12 | University of California, Los Angeles | $1,076,917 |
| 13 | Cornell University | $984,478 |
| 14 | Massachusetts Institute of Technology | $952,017 |
| 15 | Yale University | $951,084 |
| 16 | University of Pittsburgh, Pittsburgh | $939,706 |
| 17 | University of Minnesota, Twin Cities | $921,681 |
| 18 | New York University | $917,744 |
| 19 | Texas A&M University, College Station | $905,474 |
| 20 | Columbia University in the City of New York | $893,062 |
Source: Penn Center for Innovation
Source: Pennovation
| Rank | Institution |
| 1 | University of Utah |
| 2 | Columbia University |
| 3 | University of Florida |
| 4 | Brigham Young University |
| 5 | Stanford University |
| 6 | University of Pennsylvania |
| 7 | University of Washington |
| 8 | Massachusetts Institute of Technology |
| 9 | California Institute of Technology |
| 10 | Carnegie Mellon University |
| Rank | Institution | Country |
| 1 | Stanford University | USA |
| 2 | Massachusetts Institute of Technology | USA |
| 3 | Harvard University | USA |
| 4 | University of Pennsylvania | USA |
| 5 | University of Washington | USA |
| 6 | University of Texas System | USA |
| 7 | KU Leuven | Belgium |
| 8 | Imperial College London | UK |
| 9 | University of North Carolina, Chapel Hill | USA |
| 10 | Vanderbilt University | USA |
Penn Faculty, 2018
Since 1998